| Customization: | Available |
|---|---|
| CAS No.: | Drug Peptides |
| Formula: | Anti-Cancer Peptide |
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| Product Name | PNC27 |
| Assay | Above 99% |
| Appearance | Lyophilized Powder |
| Grade | Comestic Grade |
| Place of Origin | China |
| Package | 10 Vials/Box |
| MOQ | 1 Box |
| Delivery | Within 24 Hours |
| Storage | Cool Dry Place |
| Shelf Life | 2 years |
PNC-27,
Anti-cancer peptide, is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells. The peptide induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis (cell death).
PNC-27 has shown to be highly effective in selectively targeting a wide variety of specific forms of cancer, including pancreatic cancer, breast cancer, leukemia, melanoma, and additional cancer lines.
Purpose: PNC-27, a peptide that contains an HDM-2-binding domain from p53 attached to a membrane-penetrating peptide on its carboxyl terminal end, is cytotoxic to cancer, but not normal, cells. It forms transmembrane pores in the cancer cell membrane. Our purpose is to determine if the whole peptide or critical fragments induce pore formation in cancer cells.
Methods: We have prepared PNC-27 with a green fluorescent label on its amino terminus and a red fluorescent label on its carboxyl terminus and treated MCF-7 breast cancer cells and untransformed MCF-10-2A breast epithelial cells with this double-labeled peptide to determine if combined yellow fluorescence occurs in the membrane of the cancer cells during cancer cell killing.
Results: At 30 min, there is significant combined punctate yellow fluorescence, indicative of intact peptide, in the cell membrane of cancer cells that increases during cancer cell lysis. MCF-10-2A cells show initial (30 min) uniform combined yellow membrane fluorescence that subsequently disappears. Unlike the cancer cells, these untransformed cells remain viable.
1. GMP factory guarantee good quality.
2. Offer factory competitive prices.
3. Rich experience for safe and fast shipping.
4. Twenty-four hours on-time service.
A: Contact us via email or Whatsapp/telegram. Average response time is 0-4 hours during working hours and less than 24 hours during non-working hours.
Q2: How to send order?
A: Send order list to us, we quote best price for you, then ship package out and offer tracking nubmer to you after payment send.
Q3: How to confirm the product quality before placing an order?
A: 1. You can get some samples of products.
2. You can also send us the specifications or your requirements, and we will customize the product for you.
Q4: Do you have samples for our reference?
A: Sure, we can offer free samples, the customers will pay the freight.
Q5: Any discount if order more?
A: Sure, the price is negotiable, you can get much better price if order big quantity.
Q6: Is there any possible to use my appointed label or package?
A: Yes. If needed, we'd like to use label or package according to your requirement.
Q7: What about the delivery time?
A: Ship within 1-2 days after confirming payment (excluding Chinese holidays). 5-10 working days to arrive your address.
Q8: What kind of payment terms do you accept?
A:Payment can be made by Bank transfer, BTC, Credite Card, TT, Paypal, Alipay, Wechat, Visa,Mastercard, Appple Pay, Goolge Pay etc.
Q9: How to preserve peptides after receiving them?
A: Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.
Q10: What is your MOQ?
A: The minimum quantity we can order is 1kit.
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